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What is CBG and How Does it Work? (Cannabigerol)

What is CBG and How Does it Work? (Cannabigerol)

In this guide, we are going to talk about what we know about CBG or cannabigerol. It’s one of the lesser found and lesser-known cannabinoids in the cannabis plant but it has some powerful abilities. 

We are going to go through all the research we can find to let you know what the latest is on this mystery cannabinoid. Because of the laws in this country, we cannot make any medical claims but we aim to tell you how CBG interacts with your body and the potential effects that may have, along with what the latest research is suggesting.

Cannabigerol is an amazing cannabinoid, it actually creates all the other cannabinoids. 

Yes, you heard me, all other phytocannabinoids like THC and CBD actually come from CBG.

How is CBG Made?

CBG is often referred to as the stem cell of the cannabinoids because of the fact that it is the beginnings of over 100 known cannabinoids.

Pretty much everything that happens in the cannabis plant occurs because of biosynthesis. Biosynthesis is the combination of chemical compounds to create new chemical compounds. 

In the cannabis plant there are two main chemical compounds that start the life of all pytocannabinoids.

  • Olivetolic acid (OLA).
  • Geranyl pyrophosphate (GPP or sometimes GDP).

In the cannabis plant, geranyl pyrophosphate and olivetolic acid combine to produce cannabigerolic acid (CBG-A).

From there the CBG-A is broken down by enzymes in the plant to create the three main trunks of cannabinoids, THC-A, CBD-A and CBC-A.

Geranyl Pyrophosphate + Olivetolic Acid > CBGA + Enzymes > THC-A, CBD-A, CBC-A…

The type of enzymes determine which path the cannabinoid takes.

What is CBG Good For?

CBG is rumoured to help with many things but research is still early days and there is lots to learn but we will talk about what research has been done and some of the other potential benefits.

At the University of Reading in the UK research was done that showed an increase in appetite when taking CBG, so it could be good for helping people eat. 2016 research. 2017 research.

Cancerous cell growth was measured in colon cancer cells and CBG was found to inhibit the progression and growth of colon cancer cells.

A 2013 study suggests that CBG could help Irritable bowel syndrome(IBS). Plus A 2015 study suggests neuroprotective qualities in Huntington’s disease.

There is no doubt that there is lots more to find out and there are likely many other benefits of CBG yet to be found and proven. 

How CBG Works In The Body

CBG is known to interact with the CB1 receptor like anandimide and THC.

It is also shown to interact with the CB2 receptors but we are not sure if promotes or inhibits them.

CBG is a highly potent alpha-2-adrenoceptor agonist which is a receptor in the central nervous system that can affect many things like insulin release in the pancreas.

CBG is non psychoactive meaning it does not get you high

It also is a moderately potent 5-HT1A-receptor antagonist, giving it a wide range of potential therapeutic uses as an antidepressant, for the treatment of psoriasis, and as an analgesic.

It also exhibits GABA uptake inhibition to a greater extent than THC or CBD. This can help with decrease anxiety and muscle tension similar to the effects of cannabidiol (CBD) by inhibiting nerve transmission in the brain.

So as you can see, loads of benefits, there doesn’t seem to be any side effects so no doubt CBG is another great and promising cannabinoid.

See you next time!

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